DMG Supplements: Benefits, Testing, and Recommendations

What Separates DMG From Other Types of Supplements?

DMG is a glycine-derivative amino acid classified as a food substance, not a mineral or vitamin. Even though it is found in foods such as beans and organ meat (like liver), it only exists in trace amounts.

The human body can synthesize significant amounts of dimethylglycine by metabolizing choline or losing one trimethylglycine methyl group through the homocysteine pathway. However, DMG is broken down so quickly and used in so many different pathways that its levels are spread thin and never get a chance to build up. As such, the most effective way of increasing quantities of dimethylglycine in the human body is through supplementation.

Because DMG is such a potent metabolic enhancer, it supports a plethora of systems in the human body.* It’s similar to the amino acid, glycine,
but with two methyl groups attached. When DMG gives up these methyl groups to the one-carbon pathway’s methyl pool, they become part of the molecular building blocks that produce everything from neurotransmitters and hormones to nucleic acids and mitochondrial function.* Much of the scientific focus around DMG has been geared towards improved cellular energy levels, immune function, and advanced glutathione production.*

Because of DMG’s methyl donating properties, it helps recycle SAMe and Glutathione, the latter of which is a critical aspect of the human body’s detoxification process of both endogenous and xenobiotic compounds.* Glutathione is also one of the most impactful free-radical scavengers that humans, plants, and animals produce.*

Although a handful of foods contain glutathione, historically, it has low bioavailability. Our bodies need the raw materials for the glutathione synthesis process, and DMG is an efficient fuel by supplying both a methyl group and glycine for its production. Supporting glutathione production through the enhanced methylation and building-blocks provided by DMG is critical to liver health and supporting natural detoxification and the scavenging of free-radicals.*

DMG has proven to be a comprehensive cellular metabolite that can boost various physiological functions to support optimal wellbeing and overall health.* DMG raises the efficiency and productivity of the methylation metabolic pathway, showing us that this upstream cellular support may be beneficial in supporting as well as minimizing several bodily functions.*

Key Benefits of DMG

• DNA replication and repair*

• Immune response as a metabolic enhancer*

• Supports cardiovascular health*

• Supports liver health & detox*

• Supports brain health and cognition*

• Supports respiratory function through improved circulation and oxygen utilization*

• Stress support*

• Free-radical support through glutathione recycling*

• Supports healthy aging*

• Improves athletic performance*

DaVinci Laboratories has three U.S. Patents for N, N-Dimethylglycine’s value and use in improving immunity and benefiting cellular processes.*

Third-Party Testing for DMG

DaVinci® utilizes rigorous testing protocols to ensure that our labels meet or exceed all label claims and are not misleading. Our products are produced following current good manufacturing procedures( cGMP) to ensure that they meet the highest quality control standards. Our DMG is tested in its raw form by third-parties using top of the line instrumental analysis, including:

• Infrared analysis

• Nuclear magnetic resonance

• Gas-liquid chromatography/mass spectroscopy

Through these processes, we can accurately measure the quantitative amount and purity of N N-Dimethylglycine. We also employ third-party testing to verify and ensure our products meet our standards and FDA standards for contaminants like heavy metals and microbes.

DaVinci Laboratories looks for other physical aspects as well, such as particle size, melting-point determination, color, and taste, to ensure consistency across every batch we produce.

SUPPORTIVE DMG-BASED CLINICAL TRIALS

1. Immunomodulating properties of dimethylglycine in humans: C D Graber, J M Goust, A D Glassman, R Kendall, C B Loadholt

The results of this 1981 double-blind placebo-controlled study with 20 human volunteers showed that DMG enhances humoral and cell-mediated immune response in humans.*

The researchers presumed DMG had potential as an immunomodulator because of studies done on calcium pangamate.* The study proved that the test group taking DMG had a greater than fourfold increase in antibody response to the pneumococcal vaccine as compared to the control group.* The DMG group also had a significantly higher overall response of leukocyte streptokinase-streptodornase, showing that it enhances the cell-mediated response as well.*

2. Dimethylglycine Deficiency and the Development … : Martin Magnusson, Thomas J. Wang, Clary Clish, Gunnar Engström, Peter Nilsson, Robert E. Gerszten, and Olle Melander

Researchers conducted a study in 2015 to investigate N, N Dimethylglycine, and its association with insulin resistance and metabolic traits using mass spectrometry-based metabolic approaches.*

Results showed consistent data points to the possibility of DMG deficiency playing a causal role in insulin resistance development. This study sparks the need for further studies to examine the inhibition of DMG-dehydrogenase (possible protective effects of DMG on glucose metabolism DMGDH-catalyzed reaction) and points to possibilities that DMG supplementation may be useful to maintain a normal insulin response.*

3. Stimulation of the Immune Response by Dimethylglycine, a Non-toxic Metabolite,: Reap,E and Lawson J

In 1990, researchers studied the impact of DMG on the immune response in New Zealand white rabbits. A group of rabbits were fed DMG for 14 days leading up to being exposed to immunocompromising factors.

The animals given DMG demonstrated a fourfold increase in mean antibody titer compared to controls.* Animals that were given DMG showed a tenfold increase in mean lymphocyte proliferative response (p = 0.0024) and a fourfold increase of lymphocyte production ( p = 0.0180).* This trial confirmed the results of the Grabor study that DMG can enhance both the humoral and cell-mediated response. No adverse effects or toxicity was observed at any time during the trial.

4. N, N-Dimethylglycine Decreases Oxidative Stress and Improves In Vitro Development of Bovine Embryos: Toshikiyo T and et al

In 2016, researchers tested the cellular protective capabilities of DMG using early-development stage bovine embryos produced in vitro, which are known to be sensitive to reactive oxygen species.

After in vitro fertilization, presumptive zygotes were cultured with or without 0.1 μM DMG under different oxygen tensions. Findings proved that DMG enhanced the in vitro development of IVP bovine embryos by acting as a free-radical fighter.*

5. Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice: Kaiwen Bai, Wen Xu, Jingfei Zhang, Tao Kou, Yu Niu, Xiaoli Wan, Lili Zhang, Chao Wang, Tian Wang

In this 2016 study, researchers compared the free-radical fighting abilities of DMG-Na and commonly used antioxidants, Trolox (6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid) against ABTS, DPPH, and H2O2.*

The goal was to test to see if lipid peroxidation’s contribution to the development of oxygen radical-related cell membrane damage could be reduced through enhanced antioxidant efforts. The free-radical scavenging activities of DMG proved to be the highest at 40mg/ml.*

Gastric intubation in mice with 12 mg DMG-Na/0.3 ml sterile saline solution significantly increased (P < 0.05) the body weight (BW) (28 d), organ proportion (liver and spleen), and antioxidant capacity in serum and the liver (Superoxide dismutase (SOD), Hydrogen peroxidase (CAT), Glutathione peroxidase (GPx), and Total antioxidant capacity (T-AOC).* These results indicate that DMG-Na could protect against the LPS-induced oxidative stress by enhancing the free radical scavenging capacity and increasing the activity of antioxidant defense systems.*

6. Effect of a Nutritional Supplement Containing N, N –dimethylglycine (DMG) on Racing Standardbred. Equine Practice: Levine, S, and et al

This study demonstrated that when DMG is made part of an equine’s diet, it can effectively reduce the build-up of lactic acid in the horses showing how DMG can improve their racing performance.* The horses on DMG were more aggressive, have better appetites and attitudes, and recover faster from racing and training than the control group of horses that did not receive the DMG.*

Daily System-Specific REcommended DMG Amounts

Support for Overall Health and Healthy Aging* | 125-500 mg Support for Blood Sugar & Normal Insulin Response* | 375-1000 mg Support for Sports

Practice & Fitness* | 375-1000 mg
Support for Endurance Sports* | 1000-2500 mg

Healthy Immune Support* | 375-750 mg

Cardiovascular & Circulatory Support* | 375-1000 mg Neurological & Behavioral Support* | 375-1000 mg

Stress Support* | 250-750 mg

Support for Respiratory Function* | 750-1000 mg

Support for Liver Function & Detox* | 750-1000

Daily Energy Support* | 1000-1500 mg

DaVinci Supplements Containing DMG

ALLER-DMG™

Aller-DMG™ is an advanced supplement that supports healthy histamine levels and immune system function.* With DMG, Grape Seed Extract, Quercetin, Bromelain, N-Acetyl Cysteine, Vitamin C, no other formula on the market contains all of these well-researched nutrients combined into one great formula to help support proper immune & respiratory function and comfort*. Learn More

GLUCONIC® DMG

GLUCONIC® DMG is a dietary supplement to support the immune system, circulatory, cardiovascular, neurological functions, muscle recovery, and endurance.* Gluconic® DMG is an adaptogen that can be used to maintain good health and benefit performance and productivity.* As a metabolic enhancer, DMG supports the body in times of stress, throughout the aging process, and during immune system challenges.* Learn More

GLUCONIC® DMG LIQUID

This is a dietary supplement to support the immune system, circulatory, cardiovascular and neurological functions, as well as muscle recovery and endurance.* DMG supports lactic acid metabolism during workouts, thereby supporting recovery and endurance.* Learn More

BEHAVIOR BALANCE-DMG

Behavior Balance-DMG™ is an advanced nutritional supplement that combines our patented N, N-Dimethylglycine (DMG) with betaine, folic acid, vitamins E, B6 and B12, l-carnosine, zinc, and magnesium in an easy to swallow enteric-coated capsule. Learn More

BEHAVIOR BALANCE-DMG™ LIQUID

Behavior Balance-DMG™ Liquid is an advanced, Phenol free, nutritional supplement that combines our patented N, N-Dimethylglycine (DMG) with Betaine, Folic Acid, Vitamins B6 and B12, Zinc, and Magnesium in a great tasting, natural black cherry-flavored liquid. These nutrients work synergistically to support stress coping mechanisms and immune system function.* Learn More

IMMUNO-DMG™ CHEWABLE

Immuno-DMG™ Chewable with Elderberry and Vitamin D3 is an advanced nutritional supplement combining Gluconic® DMG, Maitake PD-Fraction® (Maitake Mushroom Extract), and Larch Tree Arabinogalactan Powder with Beta 1,3 Glucans. Learn More

COQ10 - DMG

A dietary supplement to support heart health and energy function.* Ingredients include 300 mg of DMG, 300 mg of COQ10, and 5 IU of Vitamin E. Other ingredients include: mannitol powder, xylitol, stearic acid, silicon dioxide, vegetable stearate, and citric acid. Learn More

NEURO-DMG™

A dietary supplement to support brain and neurological functions.* This formula was designed for individuals who have difficulty with memory or recall, thought focus, and following information or conversations.* Learn More

MULTIPHASE DETOX™*

MultiPhase Detox™* combines various minerals, herbs, antioxidants, glutathione precursors, amino acids, DMG, and three patented ingredients that are known to support bioavailability and liver health.* Learn More

PERNA® PLUS

A dietary supplement to support proper joint and connective tissue functions.* The effectiveness of Perna® Plus is due to the unique biological activity of the many identified nutrients in the Perna mussel combined with Glucosamine, Methylsulfonylmethane (MSM), Dimethylglycine (DMG), and Manganese. Learn More