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Nutritional Support for Patients on GLP-1 Weight Management Programs*

person kayaking in the desert

 

With the widespread adoption of GLP-1 agonists, practitioners are seeking ways to support their patients who are using these interventions. Also known as semaglutides, GLP-1 agonists promote metabolic wellness and a healthy body weight. They do this by mimicking glucagon-like peptide-1 (GLP-1), a hormone made naturally in the human gut. GLP-1 increases insulin release, slows gastric emptying, and controls appetite, which leads to improved blood glucose balance and a healthy body weight. While GLP-1 agonists can play a valuable role in health goals, 42% of patients are concerned about potential unwanted outcomes of semaglutides.¹

 

DaVinci® Laboratories offers a range of nutritional support options for common unwanted effects of semaglutides.* Together with diet and lifestyle changes, they can provide a comprehensive program for achieving metabolic health and body weight goals.*

 

COMMON UNDESIRABLE OUTCOMES OF GLP-1 AGONIST USE

 

Patients taking GLP-1 agonists most commonly complain of gastrointestinal effects,2 such as unsettled stomach, upset GI tract, variable bowel movements or trouble with elimination, abdominal discomfort, and gastroesophageal discomfort. The most common complaint of semaglutide use is stomach upset.1 There may also be issues with energy levels, mood, or mental clarity. Head discomfort is sometimes reported.3

 

Nutrient deficiencies are a higher risk for those taking GLP-1 agonists because of decreased appetite and reduced food intake.4 Eating less can decrease muscle mass.5 Many clinicians recommend diet and lifestyle support for patients on GLP-1 agonists, such as protein, fiber, vitamin B12, calcium, and vitamin D.6 Helping address these unwanted outcomes with nutritional supplements can improve patient compliance and wellbeing as well as help them reach their health goals.*

GLP-1_table1

 

Dehydration is a common undesirable outcome of GLP-1 agonists due to increased fluid loss from irregular gastrointestinal health.2 Therefore, adequate hydration with typically 64-80 ounces of water per day is important.

Nutritional Support for glp-1 weight management programs*

 

A foundational nutritional plan is an important first step for individuals taking GLP-1 agonists. Some individuals who are recommended GLP-1 agonists already struggle to meet their everyday nutritional requirements.7

DaVinci® Laboratories offers a foundational combination of basic vitamins, minerals, essential fatty acids, fiber, and probiotics for optimum wellness and weight management.* These should be used as part of a comprehensive weight management program, which includes a whole foods diet, proper hydration, and regular exercise.

 

Metabolic Multi is the perfect multivitamin-mineral supplement for anyone on a weight management program or who wants to support metabolic health.* It is formulated with bioavailable nutrients and ingredients known to maximize healthy levels of GLP-1 and promote metabolic health and energy, as well as a lean physique.*

Mega Probiotic™ ND 50 supports microbiome balance, digestive health, and general wellness as part of a healthy lifestyle.* A healthy gut microbiome supports GLP-1 levels in the normal range.*

Prebiotic Fiber™ promotes bowel regularity, a balanced gut microbiome, and digestive comfort, and may support healthy metabolic function.*

Omega-3 HP-D promotes a healthy inflammatory response, supports cardiometabolic health, and aids cellular and skin health.*

Beyond the foundational plan, specific nutritional support should be tailored to individuals seeking to maintain wellness while using GLP-1 agonists, including support for overall gastrointestinal and neurological health. DaVinci® Laboratories supplements can help to support systems of the body that may be impacted by GLP-1 agonists.* Refer to Table 2. Nutritional Supplements That Support Patients on GLP-1 Agonists.

GLP-1_table2

References:

  1. Polito, Rick. "NBJ: The … Effect.” Nutrition Business Journal, 2025. CRN webinar.

  2. Kommu S, Whitfield P. Semaglutide. In: StatPearls. StatPearls Publishing; 2025. Accessed April 21, 2025.

    http://www.ncbi.nlm.nih.gov/books/NBK603723/

  3. J Modestino E, Bowirrat A, Lewandrowski3 KU, et al. … Exacerbated using an Injectable GLP-1 Agonist for Weight Loss.

    Acta Sci Neurol. Published online May 1, 2024:12-18. doi:10.31080/asne.2024.07.0731

  4. Al-Massadi O, Fernø J, Diéguez C, Nogueiras R, Quiñones M. Glucagon Control on Food Intake and Energy Balance.

    Int J Mol Sci. 2019;20(16):3905. doi:10.3390/ijms20163905

  5. Ren Q, Zhi L, Liu H. Semaglutide … and Accelerated … in Older Adults with …: A 24-Month Retrospective Cohort Study.

    Drug Des Devel Ther. 2025;Volume 19:5645-5652. doi:10.2147/dddt.s531778

  6. Hanks J. Five Essential Nutrients for Patients on GLP-1s. Medscape. Accessed 2024, 2025.

    https://www.medscape.com/viewarticle/five-essential-nutrients-patients-glp-1s-2024a1000h6j

  7. Xanthakos SA. Nutritional deficiencies in ... Pediatr Clin North Am. 2009;56(5):1105-1121. doi:10.1016/j.pcl.2009.07.002
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